Vanguard^® Plus 5 L4 is for vaccination of healthy dogs 6 weeks of age or older as an aid in preventing canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine parvovirus (CPV), and leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona.

Advantages

• A microfiltration process removes extraneous protein and purifies the Leptospira fraction.
• Safety documented by large-scale, multicenter study.
• Efficacy confirmed against the most common canine Leptospira serovars.
• Demonstrated performance of the viral antigens based on retrospective serological studies.

• Vanguard® Plus 5 L4 is a freeze-dried preparation of attenuated strains of CD virus, CAV-2, CPI virus, CPV, and inactivated whole cultures of L. canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona.
• These whole Leptospira cells have been extensively rinsed, resulting in reduced extraneous materials.
• Twenty-five-1mL doses per carton.

• General Directions: Vaccination of healthy dogs 6 weeks of age or older is recommended. Aseptically rehydrate the freeze-dried vaccine (Vanguard^® Plus 5 L4) with the sterile gel provided, shake well, and administer 1 mL subcutaneously or intramuscularly.
• Primary Vaccination: Healthy dogs should receive 2 doses administered 3 weeks apart. To avoid the potential for maternal antibody interference, dogs vaccinated at less than 9 weeks of age should receive 3 doses, each administered 3 weeks apart.
• Revaccination: Annual revaccination with a single dose is recommended, although, the attending veterinarian should determine the frequency of revaccination based on the animal's lifestyle and risk of exposure.¹

1. American Veterinary Medical Association, Position Statements on Biologics, June 2001.