Vanguard^® Plus 5 L4 CV is for vaccination of healthy dogs 6 weeks of age or older as an aid in preventing canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona.

Advantages

• A microfiltration process removes extraneous protein and purifies the Leptospira fraction.
• Safety documented by large-scale, multicenter study.
• Efficacy confirmed against the most common canine Leptospira serovars.
• Demonstrated performance of the viral antigens based on retrospective serological studies.

• Vanguard® Plus 5 L4 CV is a freeze-dried preparation of attenuated strains of CD virus, CAV-2, CPI virus, CPV and inactivated whole cultures of L. canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona.
• These whole Leptospira cells have been extensively rinsed, resulting in reduced extraneous materials.
• Twenty-five-1mL doses per carton.

• General Directions: Vaccination of healthy dogs 6 weeks of age or older is recommended. Aseptically rehydrate the freeze-dried vaccine (Vanguard^® Plus 5 L4) with the accompanying vial of liquid vaccine (Vanguard CV), shake well, and administer 1 mL subcutaneously or intramuscularly.
• Primary Vaccination: Healthy dogs should receive 2 doses administered 3 weeks apart followed by a single dose of Vanguard CV 3 weeks later. To avoid the potential for maternal antibody interference, dogs vaccinated at less than 9 weeks of age should receive 3 doses of the combination vaccine, each administered 3 weeks apart.
• Revaccination: Annual revaccination with a single dose is recommended, although, the attending veterinarian should determine the frequency of revaccination based on the animal's lifestyle and risk of exposure.¹

1. American Veterinary Medical Association, Position Statements on Biologics, June 2001.